Home Current issue Ahead of print Search About us Editorial board Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 190
  • Home
  • Print this page
  • Email this page
Year : 2017  |  Volume : 9  |  Issue : 2  |  Page : 67-71

Unveiling the hidden effects of chemoradiotherapy in the treatment of oral squamous cell carcinoma: A cytological study

1 Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India
2 Department of Public Health Dentistry, Pacific Dental College and Hospital, Udaipur, Rajasthan, India
3 Department of Public Health Dentistry, Gian Sagar Dental College and Hospital, Rajpura, Punjab, India

Correspondence Address:
Ramandeep Singh Gambhir
Department of Public Health Dentistry, Gian Sagar Dental College and Hospital, Rajpura - 140 401, Punjab
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jorr.jorr_14_17

Rights and Permissions

Aim: The most common malignancy of the oral cavity is squamous cell carcinoma, which accounts for approximately 5% of all neoplasms. Unfortunately, the great majority of these tumors are diagnosed in stages which require surgery with radio- and chemo-therapy. These treatments affect not only the malignant cells but also the healthy tissues of the patient. Therefore, the present study was conducted to detect oral cytological atypia among oral squamous cell carcinoma patients receiving chemotherapy and/or radiotherapy. Materials and Methods: Oral buccal mucosal cells were obtained from thirty cancer patients receiving radiotherapy and/or chemotherapy (ascertained as cases) and thirty cancer patients not exposed to either therapy (control) and stained with Papanicolaou stain. Pearson's Chi-square test was used for statistical significance. Results: Oral epithelial atypical features were detected in 28 patients out of 30 patients who received radiotherapy and/or chemotherapy. Atypia was not observed in the control group. Inflammatory infiltrate was identified in all the therapy-related cases. Conclusion: Radiotherapy and/or chemotherapy induce variable degrees of atypical cytological changes. Radiotherapy, though a potent tool in cancer management, can unleash the surrounding normal tissues if used without caution.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded349    
    Comments [Add]    

Recommend this journal